表观遗传学
机制(生物学)
染色质
精子
DNA甲基化
组蛋白
染色质重塑
医学
小RNA
生殖细胞
男性不育
不育
生物信息学
基因表达
生物
遗传学
怀孕
基因
认识论
哲学
作者
Xiao‐Jun Huang,Yi-Nan Jiang,Hai‐Juan Bao,Jielin Wang,Rongjin Lin,Jing Yuan,Yang Zhao,Yang Zhao,Shuo Chen
标识
DOI:10.14336/ad.2024.0126
摘要
In modern times, a notable trend toward delayed childbearing has been observed in most developed countries. As a result, sperm aging and quality loss, as well as premature ovarian failure (POF), have emerged as major causes of infertility. The pathogenesis of sperm aging and POF is complex and has not been clearly elucidated. However, evidence from some studies has linked germ cell aging to epigenetic modifications. Epigenetics refers to the heritable changes in gene expression that occur in the absence of any alterations to the gene’s nucleotide sequence. This paper systematically reviewed and analyzed the relevant literature to describe the relationship of DNA methylation, non-coding RNA regulation, histone modifications, chromatin remodeling, and RNA modifications with sperm aging and POF. In addition, we analyzed how sperm aging and POF can be mitigated via epigenetic interventions. This review could provide new therapeutic insights and guide strategies for improving sperm quality and ovarian function.
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