钌
硫化氢
甲醛
帕金森病
化学
双重角色
硫化氢
机制(生物学)
神经科学
组合化学
生物物理学
生物化学
疾病
有机化学
生物
医学
硫黄
催化作用
内科学
哲学
认识论
作者
Junyu Ren,Wenzhu Zhang,Xiaona Gao,Bo Song,Jingli Yuan
标识
DOI:10.1016/j.cej.2024.150349
摘要
Parkinson's disease (PD) is one of the most common neurodegenerative diseases caused by various complicated pathological processes. Recent studies have revealed that formaldehyde (FA) and hydrogen sulfide (H2S) are essential signal molecules closely linked to central nervous systems. Therefore, understanding the physiological functions and relationship of FA and H2S in PD is beneficial for the early diagnosis and treatment of PD. However, an effective tool that could detect and visualize FA and H2S simultaneously in PD is still lacking. Herein we report the design and synthesis of a novel dual-responsive ruthenium(II) complex-based luminescent probe, Ru-aza-NBD, for the discriminatory detection of FA and H2S in aqueous media and PD models of living cells and mouse brains. Notably, using Ru-aza-NBD as a probe, the increased level of FA and the decreased level of H2S in PD models were discovered, which revealed the negative correlation of FA and H2S in PD for the first time. Collectively, Ru-aza-NBD could be an excellent tool for further investigating the biological functions of FA and H2S in pathological processes of PD, which offers a promising approach for the exploration of the pathogenic mechanism, diagnosis and treatment of this disease.
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