曲妥珠单抗
下调和上调
癌症研究
乳腺癌
基因
癌症
转移RNA
生物
癌细胞
化学
核糖核酸
生物化学
遗传学
作者
Ningjun Duan,Yijia Hua,Xueqi Yan,Yaozhou He,Tianyu Zeng,Jue Gong,Ziyi Fu,Wei Li,Yongmei Yin
出处
期刊:Cancers
[Multidisciplinary Digital Publishing Institute]
日期:2024-03-11
卷期号:16 (6): 1118-1118
被引量:4
标识
DOI:10.3390/cancers16061118
摘要
tRNA-derived fragments (tRFs) play crucial roles in cancer progression. Among them, tRF-27 has been identified as a key factor in promoting naïve trastuzumab resistance in HER2-positive breast cancer. However, the origin of tRF-27 remains uncertain. In this study, we propose that the upregulated expression of specific cysteine tRNAs may lead to the increased accumulation of tRF-27 in trastuzumab-resistant JIMT1 cells. Mechanistically, the reduced inhibitory H3K27me3 modification at the promoter regions of tRF-27-related tRNA genes in JIMT1 cells, potentially resulting from decreased EZH2 and increased KDM6A activity, may be a critical factor stimulating the transcriptional activity of these tRNA genes. Our research offers fresh insights into the mechanisms underlying elevated tRF-27 levels in trastuzumab-resistant breast cancer cells and suggests potential strategies to mitigate trastuzumab resistance in clinical treatments.
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