医学
霍恩斯菲尔德秤
2型糖尿病
糖尿病
亚临床感染
内科学
脂肪组织
核医学
心脏病学
磁共振成像
体质指数
前瞻性队列研究
四分位间距
内分泌学
放射科
计算机断层摄影术
作者
Sarah L Ayton,Jian L Yeo,Gaurav S. Gulsin,Abhishek Dattani,Joanna Bilak,Aparna Deshpande,Jayanth R. Arnold,Anvesha Singh,Matthew Graham‐Brown,Leong L. Ng,Donald J. L. Jones,Piotr J. Slomka,Damini Dey,Alastair J Moss,Emer M. Brady,Gerry P McCann
标识
DOI:10.1016/j.ejrad.2024.111400
摘要
Abstract
Background
Dysregulated epicardial adipose tissue (EAT) may contribute to the development of heart failure in Type 2 diabetes (T2D). This study aimed to evaluate the associations between EAT volume and composition with imaging markers of subclinical cardiac dysfunction in people with T2D and no prevalent cardiovascular disease. Methods
Prospective case-control study enrolling participants with and without T2D and no known cardiovascular disease. Two hundred and fifteen people with T2D (median age 63 years, 60 % male) and thirty-nine non-diabetics (median age 59 years, 62 % male) were included. Using computed tomography (CT), total EAT volume and mean CT attenuation, as well as, low attenuation (Hounsfield unit range −190 to −90) EAT volume were quantified by a deep learning method and volumes indexed to body surface area. Associations with cardiac magnetic resonance-derived left ventricular (LV) volumes and strain indices were assessed using linear regression. Results
T2D participants had higher LV mass/volume ratio (median 0.89 g/mL [0.82–0.99] vs 0.79 g/mL [0.75–0.89]) and lower global longitudinal strain (GLS; 16.1 ± 2.3 % vs 17.2 ± 2.2 %). Total indexed EAT volume correlated inversely with mean CT attenuation. Low attenuation indexed EAT volume was 2-fold higher (18.8 cm3/m2 vs. 9.4 cm3/m2, p < 0.001) in T2D and independently associated with LV mass/volume ratio (ß = 0.002, p = 0.01) and GLS (ß = −0.03, p = 0.03). Conclusions
Higher EAT volumes seen in T2D are associated with a lower mean CT attenuation. Low attenuation indexed EAT volume is independently, but only weakly, associated with markers of subclinical cardiac dysfunction in T2D.
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