Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy

杜皮鲁玛 免疫学 医学 过敏 免疫疗法 鼻粘膜 免疫系统 哮喘
作者
Matthew F. Wipperman,Kaitlyn Gayvert,Amanda Atanasio,Claire Q. Wang,Jonathan Corren,Angelica Covarrubias,Ian Setliff,Erica Chio,Elizabeth Laws,Kelley Wolfe,Sivan Harel,Jennifer Maloney,Gary Herman,Jamie Orengo,Wei Keat Lim,Sara Hamon,Jennifer D. Hamilton,Meagan P. O’Brien
出处
期刊:Allergy [Wiley]
卷期号:79 (4): 894-907 被引量:4
标识
DOI:10.1111/all.16001
摘要

Abstract Background Nasal epithelial cells are important regulators of barrier function and immune signaling; however, in allergic rhinitis (AR) these functions can be disrupted by inflammatory mediators. We aimed to better discern AR disease mechanisms using transcriptome data from nasal brushing samples from individuals with and without AR. Methods Data were drawn from a feasibility study of individuals with and without AR to Timothy grass and from a clinical trial evaluating 16 weeks of treatment with the following: dupilumab, a monoclonal antibody that binds interleukin (IL)‐4Rα and inhibits type 2 inflammation by blocking signaling of both IL‐4/IL‐13; subcutaneous immunotherapy with Timothy grass (SCIT), which inhibits allergic responses through pleiotropic effects; SCIT + dupilumab; or placebo. Using nasal brushing samples from these studies, we defined distinct gene signatures in nasal tissue of AR disease and after nasal allergen challenge (NAC) and assessed how these signatures were modulated by study drug(s). Results Treatment with dupilumab (normalized enrichment score [NES] = −1.73, p = .002) or SCIT + dupilumab (NES = −2.55, p < .001), but not SCIT alone (NES = +1.16, p = .107), significantly repressed the AR disease signature. Dupilumab (NES = −2.55, p < .001), SCIT (NES = −2.99, p < .001), and SCIT + dupilumab (NES = −3.15, p < .001) all repressed the NAC gene signature. Conclusion These results demonstrate type 2 inflammation is an important contributor to the pathophysiology of AR disease and that inhibition of the type 2 pathway with dupilumab may normalize nasal tissue gene expression.
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