Fused‐Ring Pyrrole‐Based Near‐Infrared Emissive Organic RTP Material for Persistent Afterglow Bioimaging

磷光 材料科学 发光 红外线的 光电子学 磷光有机发光二极管 余辉 有机发光二极管 光化学 纳米技术 荧光 化学 光学 图层(电子) 天文 物理 伽马射线暴
作者
Yeyun Zhao,Jianhui Yang,Chao Liang,Li Wang,Yongfeng Zhang,Gengchen Li,Jiamin Qu,Xi Wang,Yahui Zhang,Peng Sun,Jianbing Shi,Bin Tong,Hai‐Yan Xie,Zhengxu Cai,Yuping Dong
出处
期刊:Angewandte Chemie [Wiley]
卷期号:63 (5) 被引量:19
标识
DOI:10.1002/anie.202317431
摘要

Abstract Organic near‐infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scales and background noise elimination. However, developing near‐infrared RTP materials for deep tissue imaging still faces challenges since the small band gap may increase the non‐radiative decay, resulting in weak emission and short phosphorescence lifetime. In this study, fused‐ring pyrrole‐based structures were employed as the guest molecules for the construction of long wavelength emissive RTP materials. Compared to the decrease of the singlet energy level, the triplet energy level showed a more effectively decrease with the increase of the conjugation of the substituent groups. Moreover, the sufficient conjugation of fused ring structures in the guest molecule suppresses the non‐radiative decay of triplet excitons. Therefore, a near‐infrared RTP material (764 nm) was achieved for deep penetration bioimaging. Tumor cell membrane is used to coat RTP nanoparticles (NPs) to avoid decreasing the RTP performance compared to traditional coating by amphiphilic surfactants. RTP NPs with tumor‐targeting properties show favorable phosphorescent properties, superior stability, and excellent biocompatibility. These NPs are applied for time‐resolved luminescence imaging to eliminate background interference with excellent tissue penetration. This study provides a practical solution to prepare long‐wavelength and long‐lifetime organic RTP materials and their applications in bioimaging.
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