脱氢
化学
催化作用
镍
芳基
配体(生物化学)
组合化学
选择性
小学(天文学)
有机化学
偶联反应
天文
生物化学
物理
受体
烷基
作者
Sadhna Bansal,Benudhar Punji
标识
DOI:10.1002/chem.202304082
摘要
Chemodivergent (de)hydrogenative coupling of primary and secondary alcohols is achieved utilizing an inexpensive nickel catalyst, (6-OH-bpy)NiCl2. This protocol demonstrates the synthesis of branched carbonyl compounds, α,α-disubstituted ketones, and α-substituted chalcones via borrowing hydrogen strategy and acceptorless dehydrogenative coupling, respectively. A wide range of aryl-based secondary alcohols are coupled with various primary alcohols in this tandem dehydrogenation/hydrogenation reaction. The nickel catalyst, along with KOtBu or K2CO3, governed the selectivity for the formation of branched saturated ketones or chalcones. A preliminary mechanistic investigation confirms the reversible dehydrogenation of alcohols to carbonyls via metal-ligand cooperation (MLC) and the involvement of radical intermediates during the reaction.
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