Most seismicity in Latin America is controlled by the subduction process. Different zones have hosted earthquakes of magnitudes larger than Mw 8.5 that repeat every several centuries. Events around Mw 8.0 are more frequent; since the beginning of the twentieth century, some collocated earthquakes have occurred with differences of decades, which allows for comparison of old and modern seismological records. The rupture zones that have hosted mega-earthquakes continue to produce smaller earthquakes after three centuries. Therefore, the process of unlocking in the Latin America subduction zone occurs by giant (≥Mw 9.0), mega- (9.0 > Mw ≥ 8.5), and large (8.5 > Mw ≥ 7.5) earthquakes, and interaction between these events is not yet fully understood. We have less understanding of the earthquakes that occurred in the oceanic plates, which have not been correctly recorded due to poor seismological instrumentation and lack of knowledge about subduction during the first half of the twentieth century in Latin America. Slow earthquakes have been observed in some zones of Latin America, several of them with recurrence periods of a few years, as well as tectonic (nonvolcanic) tremors and low-frequency and very low-frequency earthquakes. How do these slow slip manifestations relate to ordinary earthquakes? This question is still difficult to answer for Latin America given the lack of dense geodetic and seismic networks that allow identification of all the slow earthquakes that likely occur more frequently than currently reported. ▪ Latin America subduction zones share similar seismic characteristics. They can host large-magnitude earthquakes and exhibit a variety of slow earthquakes. ▪ Giant earthquakes, with a magnitude greater than 9, have occurred so far in Chile, and mega-earthquakes have occurred in several Latin American countries. ▪ Additional slow earthquakes will be detected in Latin America as seismic and geodetic networks become denser.