Experimental and Computational Investigation of Cu(II) and Zn(II) complexes: DFT, Docking, and Anti-Lung Cancer Studies

Aims This study aimed to synthesize and characterize a Schiff base ligand, (Z)-2-(2-oxoindolin-3-ylidene)hydrazinecarbothioamide (1), and its copper(II) (2) and zinc(II) (3) complexes, as well as evaluate their binding interactions with the epidermal growth factor receptor (EGFR) and anticancer activity against the human lung cancer A549 cell line.