免疫原性
免疫系统
铜绿假单胞菌
接种疫苗
细菌外膜
细菌
抗生素
体内
免疫
抗原
病菌
微生物学
免疫学
生物
生物化学
大肠杆菌
基因
生物技术
遗传学
作者
Ilkoo Noh,Zhongyuan Guo,Jiarong Zhou,Weiwei Gao,Ronnie H. Fang,Liangfang Zhang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-11-28
卷期号:17 (2): 1120-1127
被引量:19
标识
DOI:10.1021/acsnano.2c08360
摘要
Vaccination has become an increasingly attractive strategy for protecting against antibiotic-resistant infections. Nanovaccines based on the outer membrane from Gram-negative bacteria are appealing due to their multiantigenic nature and inherent immunogenicity. Here, we develop cellular nanodiscs made of bacterial outer membrane (OM-NDs), as a platform for antibacterial vaccination. Using Pseudomonas aeruginosa as a model pathogen, the resulting OM-NDs can effectively interact with antigen-presenting cells, exhibiting accelerated uptake and an improved capacity for immune stimulation. With their small size, the OM-NDs are also capable of efficiently transporting to the lymph nodes after in vivo administration. As a result, the nanovaccine is effective at eliciting potent humoral and cellular immune responses against P. aeruginosa. In a murine model of pneumonia, immunization with OM-NDs confers strong protection against subsequent lung infection, resulting in improved survival, reduced bacterial loads, and alleviation of immune overactivation. Overall, this report illustrates the advantages of cellular nanodiscs, which can be readily generalized to other pathogens and may be applied toward other biomedical applications.
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