清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Meta-analysis addressing the characterization and risk identification of antibiotics and antibiotic resistance genes in global groundwater

抵抗性 抗生素耐药性 地下水 酸杆菌 生物 抗生素 危险系数 放线菌门 生物技术 生态学 微生物学 遗传学 细菌 污染 整合子 工程类 岩土工程 16S核糖体RNA
作者
Chang Liu,Jinping Chen,Xin Shan,Yuyi Yang,Liuting Song,Yanguo Teng,Haiyang Chen
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:860: 160513-160513 被引量:33
标识
DOI:10.1016/j.scitotenv.2022.160513
摘要

Antimicrobial resistance (AMR) is one of the significant global issues to public health. Compared to other aquatic environments, research on AMR in groundwater is scarce. In the study, a meta-analysis was conducted to explore the characteristics and risks of antibiotics and antibiotic resistance genes (ARGs) in global groundwater, using a data set of antibiotic concentrations collected from publications during 2000-2021 and a large-scale metagenomes of groundwater samples (n = 330). The ecotoxicological risks of antibiotics in the global groundwater were evaluated using mixture risk quotient with concentration addition model to consider the synergistic effects of multiple antibiotics. Bioinformatic annotations identified 1413 ARGs belonging to 37 ARG types in the global groundwater, dominated by rifamycin, polyketide, and quinolone resistance genes and including some emerging ARGs such as mcr-family and carbapenem genes. Relatively, the level of ARGs in the groundwater from spring was significantly higher (ANOVA, p < 0.01) than those from the riparian zone, sand and deep aquifer. Similarly, metal resistance genes (MRGs) were prevalent in the global groundwater, and network analysis suggested the MRGs presented non-random co-occurrence with the ARGs in such environments. Taxonomic annotations showed Proteobacteria, Actinobacteria, Eukaryota, Acidobacteria and Thaumarchaeota were the dominant phylum in the groundwater, and the microbial community largely shaped profile of ARGs in the environment. Notably, the ARGs presented co-occurrence with mobile genetic elements, virulence factors and human bacterial pathogens, indicating potential dissemination risk of ARGs in the groundwater. Furthermore, an omics-based approach was used for health risk assessment of antibiotic resistome and screened out 152 risk ARGs in the global groundwater. Comparatively, spring and cold creek presented higher risk index, which deserves more attention to ensure the safety of water supply.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
六一儿童节完成签到 ,获得积分10
2秒前
4秒前
diyanbruker发布了新的文献求助10
10秒前
英喆完成签到 ,获得积分10
23秒前
蚂蚁踢大象完成签到 ,获得积分10
34秒前
35秒前
48秒前
超男完成签到 ,获得积分10
48秒前
科研通AI2S应助科研通管家采纳,获得10
50秒前
50秒前
qing发布了新的文献求助10
51秒前
xiaozou55完成签到 ,获得积分10
58秒前
ycp完成签到,获得积分10
58秒前
量子星尘发布了新的文献求助10
1分钟前
貔貅完成签到 ,获得积分10
1分钟前
AAAAA完成签到,获得积分20
1分钟前
AAAAA发布了新的文献求助10
1分钟前
跳跃的鹏飞完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
qing发布了新的文献求助10
1分钟前
zts发布了新的文献求助10
1分钟前
文与武完成签到 ,获得积分10
1分钟前
百里守约完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
MissGrrrace发布了新的文献求助10
2分钟前
qing发布了新的文献求助10
2分钟前
wujiwuhui完成签到 ,获得积分10
2分钟前
小强完成签到 ,获得积分10
2分钟前
MissGrrrace完成签到,获得积分10
2分钟前
量子星尘发布了新的文献求助10
2分钟前
Sandy应助科研通管家采纳,获得20
2分钟前
薄荷完成签到,获得积分10
2分钟前
缺粥完成签到 ,获得积分10
3分钟前
3分钟前
称心如意完成签到 ,获得积分10
3分钟前
3分钟前
薄荷发布了新的文献求助10
3分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976683
求助须知:如何正确求助?哪些是违规求助? 3520788
关于积分的说明 11204819
捐赠科研通 3257565
什么是DOI,文献DOI怎么找? 1798756
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806648