肝细胞癌
肝再生
再生(生物学)
薄壁组织
生物
病理
肝小叶
平衡
肝癌
肝实质
医学
癌症研究
细胞生物学
作者
María del Mar Rigual,Paula Sánchez Sánchez,Nabil Djouder
标识
DOI:10.1016/j.trecan.2022.10.005
摘要
The liver is the largest organ of the mammalian body and has the remarkable ability to fully regenerate in order to maintain tissue homeostasis. The adult liver consists of hexagonal lobules, each with a central vein surrounded by six portal triads localized in the lobule border containing distinct parenchymal and nonparenchymal cells. Because the liver is continuously exposed to diverse stress signals, several sophisticated regenerative processes exist to restore its functional status following impairment. However, these stress signals can affect the liver's capacity to regenerate and may lead to the development of hepatocellular carcinoma (HCC), one of the most aggressive liver cancers. Here, we review the mechanisms of hepatic regeneration and their potential to influence HCC development.
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