立体中心
化学
对映选择合成
催化作用
脱羧
酰胺
产量(工程)
钯
组合化学
有机化学
立体化学
冶金
材料科学
作者
Shu-Pei Yuan,Qing Bao,Ting-Jia Sun,Jian‐Qiang Zhao,Zhen‐Hua Wang,Yong You,Yanping Zhang,Ming‐Qiang Zhou,Wei‐Cheng Yuan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-11-10
卷期号:24 (45): 8348-8353
被引量:24
标识
DOI:10.1021/acs.orglett.2c03383
摘要
A palladium-catalyzed enantioselective α-allylation of deconjugated butenolides with aza-π-allylpalladium 1,4-diploes, in situ generated from palladium-mediated decarboxylation of cyclic carbamates and amide-substituted acyclic carbonates, has been successfully developed. An array of enantioenriched 2-piperidones bearing an all-carbon quaternary stereocenter were obtained in high yields with excellent enantioselectivities (up to 99% yield and 99% ee). The utility of this method was also showcased by a large-scale reaction and synthetic transformations of the product.
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