Effects of admission systemic inflammatory indicators on clinical outcomes in patients with vertebrobasilar artery occlusion: insight from the PERSIST registry

医学 内科学 白细胞 中性粒细胞与淋巴细胞比率 改良兰金量表 逻辑回归 闭塞 多元分析 心脏病学 淋巴细胞 缺血性中风 缺血
作者
Pan Zhang,Pengfei Xu,Zuowei Duan,Feng Zhang,Yirong Fang,Dingyi Yan,Hanhong Zhang,Qiankun Cai,Xianjun Huang,Zhixin Huang,Mengmeng Gu,Lulu Xiao,Jinjing Wang,Wen Sun
出处
期刊:Journal of NeuroInterventional Surgery [BMJ]
卷期号:15 (e2): e270-e276 被引量:4
标识
DOI:10.1136/jnis-2022-019437
摘要

Few studies have focused on the effect of systemic inflammation in vertebrobasilar artery occlusion (VBAO). The aim of this study was to investigate the relationship between inflammatory indicators and the prognosis of VBAO patients receiving endovascular treatment (EVT).Patients with VBAO who were treated with EVT within 24 hours of the estimated occlusion time were included in this study. Multivariate logistic regression and elastic net regularization were performed to analyze the effects of inflammatory indicators on the prognosis of patients with VBAO. The primary outcome was unfavorable outcome (a modified Rankin Scale score of 4-6) at 90 days. Secondary outcomes included symptomatic intracranial hemorrhage, in-hospital mortality, 90 day mortality, 1 year unfavorable outcome, and mortality.560 patients were included in the study. Multivariate analysis showed that white blood cells (W), neutrophils (N), neutrophil to lymphocyte ratio (NLR), platelet to neutrophil ratio, platelet to white blood cell ratio, and NLR to platelet ratio were associated with the primary outcome. Elastic net regularization indicated that W, N, and NLR were the major inflammatory predictors of unfavorable outcome at 90 days. For long term prognosis, we found that the inflammatory indicators that predicted 1 year outcomes were consistent with those that predicted 90 day outcomes.Inflammatory indicators, especially W, N, and NLR, were associated with moderate and long term prognosis of patients with VBAO treated with EVT.
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