Prognostic modeling for nasopharyngeal carcinoma (NC) undergoing concurrent chemoradiotherapy using clinical and enhanced MRI-Delta radiomics data: A preliminary study

列线图 医学 鼻咽癌 放化疗 单变量分析 内科学 卡帕 肿瘤科 多元分析 回顾性队列研究 单变量 放射科 放射治疗 多元统计 机器学习 哲学 语言学 计算机科学
作者
Li Wang,Peng An,Lina Song,Jun-Jie Liu,Jisheng Liu
出处
期刊:Technology and Health Care [IOS Press]
卷期号:32 (4): 2381-2394 被引量:1
标识
DOI:10.3233/thc-231173
摘要

BACKGROUND: Nasopharyngeal carcinoma (NC) is one of the prevalent malignancies of the head and neck region with poor prognosis. OBJECTIVE: The aim of this study is to establish a predictive model for assessing NC prognosis based on clinical and MR radiomics data, subsequently to develop a nomogram for practical application. METHODS: Retrospective analysis was conducted on clinical and imaging data collected between May 2010 and August 2018, involving 211 patients diagnosed with histologically confirmed NC who received concurrent chemoradiotherapy or radical surgery in Xiangyang No. 1 People’s Hospital. According to 5–10 years of follow-up results, the patients were divided into two groups: the study group (n= 76), which experienced recurrence, metastasis, or death, and the control group (n= 135), characterized by normal survival. Training and testing subsets were established at a 7:3 ratio, with a predefined time cutoff. In the training set, three prediction models were established: a clinical data model, an imaging model, and a combined model using the integrated variation in clinical characteristics along with MR radiomics parameters (Delta-Radscore) observed before and after concurrent chemoradiotherapy. Model performance was compared using Delong’s test, and net clinical benefit was assessed via decision curve analysis (DCA). Then, external validation was conducted on the test set, and finally a nomogram predicting NC prognosis was created. RESULTS: Univariate analysis identified that the risk factors impacting the prognosis of NC included gender, pathological type, neutrophil to lymphocyte ratio (NLR), degree of tumor differentiation, MR enhancement pattern, and Delta-Radscore (P< 0.05). The combined model established based on the abovementioned factors exhibited significantly higher predictive performance [AUC: 0.874, 95% CI (0.810–0.923)] than that of the clinical data model [AUC: 0.650, 95% CI (0.568–0.727)] and imaging model [AUC: 0.824, 95% CI (0.753–0.882)]. DCA also demonstrated superior clinical net benefit in the combined model, a finding further verified by results from the test set. The developed nomogram, based on the combined model, exhibited promising performance in clinical applications. CONCLUSION: The Delta-Radscore derived from MR radiomics data before and after concurrent chemoradiotherapy helps enhance the performance of the NC prognostic model. The combined model and resultant nomogram provide valuable support for clinical decision-making in NC treatment, ultimately contributing to an improved survival rate.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助10
1秒前
Blaseaka完成签到 ,获得积分10
2秒前
Owen应助科研通管家采纳,获得10
2秒前
深情安青应助科研通管家采纳,获得10
2秒前
2秒前
汉堡包应助科研通管家采纳,获得10
3秒前
小二郎应助科研通管家采纳,获得30
3秒前
爆米花应助科研通管家采纳,获得10
3秒前
沉静的浩然完成签到,获得积分10
4秒前
开朗的绮山完成签到,获得积分10
4秒前
4秒前
老迟到的土豆完成签到 ,获得积分10
7秒前
单薄的日记本完成签到,获得积分10
7秒前
大橙子发布了新的文献求助10
8秒前
舒适的天奇完成签到 ,获得积分10
9秒前
10秒前
12秒前
都是小儿卡通书完成签到,获得积分10
13秒前
14秒前
陶醉的又夏完成签到 ,获得积分10
14秒前
lily完成签到 ,获得积分10
17秒前
18秒前
子苓完成签到 ,获得积分10
20秒前
Jun完成签到 ,获得积分10
20秒前
phil完成签到,获得积分10
21秒前
祁乐安发布了新的文献求助20
21秒前
如初完成签到,获得积分10
22秒前
zzuwxj完成签到,获得积分10
25秒前
糊涂的语兰完成签到,获得积分10
29秒前
多余完成签到,获得积分10
30秒前
喝酸奶不舔盖完成签到 ,获得积分10
30秒前
朴实初夏完成签到 ,获得积分10
31秒前
31秒前
华仔应助查查make采纳,获得10
36秒前
乐乐应助普鲁卡因采纳,获得10
36秒前
美海与鱼完成签到,获得积分10
36秒前
哦豁完成签到 ,获得积分10
37秒前
阿钱小钱完成签到 ,获得积分10
38秒前
世上僅有的榮光之路完成签到,获得积分0
38秒前
能干的蜗牛完成签到,获得积分10
39秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022