分拣酶
生物分子
计算生物学
翻译后修饰
化学
排序酶A
范围(计算机科学)
纳米技术
生物化学
细菌蛋白
计算机科学
酶
生物
材料科学
基因
程序设计语言
作者
Nayara Braga Emídio,Ross W. Cheloha
标识
DOI:10.1016/j.cbpa.2024.102443
摘要
New applications for biomolecules demand novel approaches for their synthesis and modification. Traditional methods for modifying proteins and cells using non-specific labeling chemistry are insufficiently precise to rigorously interrogate the mechanistic biological and physiological questions at the forefront of biomedical science. Site-specific catalytic modification of proteins promises to meet these challenges. Here, we describe recent applications of the enzyme sortase A in facilitating precise biomolecule labeling. We focus on describing new chemistries to broaden the scope of sortase-mediated labeling (sortagging), the development of new probes for imaging via enzymatic labeling, and the modulation of biological systems using probes and reactions mediated by sortase.
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