表位
T细胞受体
免疫突触
抗原
生物
T细胞
人类白细胞抗原
计算生物学
基因组
免疫学
遗传学
基因
免疫系统
作者
Venkata Krishna Kanth Makani,Alok V. Joglekar
出处
期刊:Cancer immunology research
[American Association for Cancer Research]
日期:2024-04-01
卷期号:12 (5): 515-515
标识
DOI:10.1158/2326-6066.cir-24-0239
摘要
Abstract The pivotal role of T cell responses has been well studied in both protective and destructive scenarios. T cells recognize peptide epitopes presented on Human Leukocyte Antigens (HLA) through their surface T cell receptors (TCR). Advances in single-cell RNA sequencing have identified millions of TCRs, but only a minuscule fraction of them have known epitopes. Recently, cell-based T cell antigen discovery platforms have emerged onto the landscape. Here, Jin and colleagues, report a novel antigen discovery platform called Tsyn-seq that relies on sequencing TCR-peptide-HLA–induced synapses for genome-wide epitope screening. See related article by Jin et al., p. 530 (3).
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