Exploring anti‐inflammatory and antioxidant‐related quality markers of Artemisia absinthium L. based on spectrum–effect relationship

化学 DPPH 食品科学 抗氧化剂 阿布茨 绿原酸 色谱法 传统医学 生物化学 医学
作者
Ayixiamuguli Wubuli,Rahima Abdulla,Jiangyu Zhao,Tao Wu,Haji Akber Aisa
出处
期刊:Phytochemical Analysis [Wiley]
卷期号:35 (5): 1152-1173
标识
DOI:10.1002/pca.3350
摘要

Abstract Introduction Artemisia absinthium L. is a well‐known medicinal, aromatic, and edible plant with important medicinal and economic properties and a long history of use in treating liver inflammation and other diseases; however, there has been insufficient progress in quality control. Objective This study aimed to investigate the quality markers for the anti‐inflammatory and antioxidant activities of A. absinthium based on spectrum–effect relationship analysis. Materials and methods Eighteen batches of A. absinthium from different origins were used. Chemical fingerprints were obtained by ultra‐performance liquid chromatography (UPLC). The chemical compositions were identified by quadrupole‐Orbitrap high‐resolution mass spectrometry. Anti‐inflammatory activity was assessed by inhibition of cyclooxygenase‐2 and 15‐lipoxygenase in vitro and inhibition of nitric oxide release in lipopolysaccharide‐induced BV‐2 cells. Antioxidant activity was assessed by DPPH and ABTS radical scavenging assays. The relationship between bioactivity and chemical fingerprints was then analyzed using chemometrics including gray relational analysis, bivariate correlation analysis, and orthogonal partial least squares analysis. Results Different batches of A. absinthium extracts possessed significant anti‐inflammatory and antioxidant activities to varying degrees. Eighty compounds were identified from A. absinthium , and 12 main common peaks were obtained from the UPLC fingerprints. P3 (chlorogenic acid), P5 (isochlorogenic acid A), and P6 (isochlorogenic acid C) were screened as the most promising active compounds by correlation analysis and further validated for their remarkable anti‐inflammatory effects. Conclusion This is the first study to screen the quality markers of A. absinthium by establishing the spectrum–effect relationship, which can provide a reference for the development of quality standards and further research on A. absinthium .
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
自来也完成签到,获得积分10
2秒前
fang完成签到,获得积分10
4秒前
流沙无言完成签到 ,获得积分10
5秒前
10秒前
天天快乐应助Max采纳,获得10
11秒前
张庭豪完成签到,获得积分10
14秒前
雷九万班完成签到 ,获得积分10
14秒前
15秒前
SciGPT应助wang5cl采纳,获得10
16秒前
CCl完成签到 ,获得积分10
18秒前
Max完成签到,获得积分10
19秒前
芊芊完成签到 ,获得积分10
23秒前
kuyi完成签到 ,获得积分10
23秒前
诺亚方舟哇哈哈完成签到 ,获得积分0
24秒前
天行健完成签到,获得积分10
31秒前
32秒前
俏皮马里奥完成签到 ,获得积分10
36秒前
一拳一个小欧阳完成签到 ,获得积分10
36秒前
机灵石头完成签到,获得积分10
36秒前
奕泽完成签到 ,获得积分10
37秒前
Max发布了新的文献求助10
38秒前
145546完成签到 ,获得积分10
40秒前
nicky完成签到 ,获得积分10
41秒前
笑林完成签到 ,获得积分10
41秒前
42秒前
alexlpb完成签到,获得积分10
44秒前
小丑鱼儿完成签到 ,获得积分10
53秒前
勤恳的书文完成签到 ,获得积分10
55秒前
萧水白应助科研通管家采纳,获得10
57秒前
科研通AI2S应助科研通管家采纳,获得10
57秒前
Much完成签到 ,获得积分10
1分钟前
Telomere完成签到 ,获得积分10
1分钟前
拉长的诗蕊完成签到,获得积分10
1分钟前
1分钟前
doclarrin完成签到 ,获得积分10
1分钟前
richhu完成签到,获得积分10
1分钟前
十七发布了新的文献求助10
1分钟前
SAINT完成签到 ,获得积分10
1分钟前
123321完成签到,获得积分10
1分钟前
一一完成签到,获得积分10
1分钟前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3248874
求助须知:如何正确求助?哪些是违规求助? 2892264
关于积分的说明 8270362
捐赠科研通 2560537
什么是DOI,文献DOI怎么找? 1389056
科研通“疑难数据库(出版商)”最低求助积分说明 651004
邀请新用户注册赠送积分活动 627850