Noncoding RNAs in liver physiology and metabolic diseases

生物 长非编码RNA 核糖核酸 小RNA RNA结合蛋白 非编码RNA 计算生物学 表型 生物信息学
作者
Christian Sommerauer,Claudia Kutter
出处
期刊:American Journal of Physiology-cell Physiology [American Physical Society]
标识
DOI:10.1152/ajpcell.00232.2022
摘要

The liver holds central roles in detoxification, energy metabolism and whole-body homeostasis but can develop malignant phenotypes when being chronically overwhelmed with fatty acids and glucose. The global rise of metabolic-associated fatty liver disease (MAFLD) is already affecting a quarter of the global population. Pharmaceutical treatment options against different stages of MAFLD do not yet exist and several clinical trials against hepatic transcription factors and other proteins have failed. However, emerging roles of noncoding RNAs, including long (lncRNA) and short noncoding RNAs (sRNA), in various cellular processes pose exciting new avenues for treatment interventions. Actions of noncoding RNAs mostly rely on interactions with proteins, whereby the noncoding RNA fine-tunes protein function in a process termed riboregulation. The developmental stage-, disease stage- and cell type-specific nature of noncoding RNAs harbors enormous potential to precisely target certain cellular pathways in a spatio-temporally defined manner. Proteins interacting with RNAs can be categorized into canonical or non-canonical RNA binding proteins (RBPs) depending on the existence of classical RNA binding domains. Both, RNA- and RBP-centric methods have generated new knowledge of the RNA-RBP interface and added an additional regulatory layer. In this review, we summarize recent advances of how of RBP-lncRNA interactions and various sRNAs shape cellular physiology and the development of liver diseases such as MAFLD and hepatocellular carcinoma.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
tang完成签到,获得积分10
刚刚
海棠花未眠完成签到,获得积分10
刚刚
djh233发布了新的文献求助20
2秒前
曲又蓝完成签到,获得积分10
2秒前
白开水完成签到,获得积分20
3秒前
3秒前
蚂蚁Y嘿完成签到,获得积分10
4秒前
4秒前
rose完成签到,获得积分10
4秒前
ding应助Xx采纳,获得10
4秒前
4秒前
丂枧完成签到 ,获得积分10
5秒前
今后应助gao采纳,获得10
5秒前
5秒前
赘婿应助zSmart采纳,获得10
6秒前
云魂完成签到,获得积分10
6秒前
6秒前
orixero应助郭翔采纳,获得10
7秒前
余小琴完成签到 ,获得积分10
7秒前
慕青应助无奈的黑猫采纳,获得10
7秒前
Youngyoung完成签到,获得积分10
7秒前
bkagyin应助yqy1234采纳,获得10
7秒前
东东完成签到,获得积分10
8秒前
8秒前
charles发布了新的文献求助10
9秒前
cyfmlt发布了新的文献求助10
9秒前
10秒前
嘿哈发布了新的文献求助10
10秒前
yuki完成签到,获得积分10
10秒前
无限的可乐应助小红采纳,获得10
10秒前
希望天下0贩的0应助hu采纳,获得10
10秒前
凉凉应助养乐多采纳,获得10
10秒前
10秒前
elle发布了新的文献求助10
11秒前
满意黑夜完成签到,获得积分10
14秒前
14秒前
CL完成签到,获得积分10
14秒前
14秒前
英俊的铭应助李奥采纳,获得10
15秒前
ding应助elle采纳,获得10
15秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4010081
求助须知:如何正确求助?哪些是违规求助? 3550086
关于积分的说明 11304770
捐赠科研通 3284597
什么是DOI,文献DOI怎么找? 1810722
邀请新用户注册赠送积分活动 886535
科研通“疑难数据库(出版商)”最低求助积分说明 811451