Different patterns of exosomal α‐synuclein between Parkinson's disease and probable rapid eye movement sleep behavior disorder

帕金森病 医学 生物标志物 神经炎症 内科学 快速眼动睡眠 快速眼动睡眠行为障碍 疾病 眼球运动 化学 生物化学 眼科
作者
Yiqun Yan,Jiali Pu,Ran Zheng,Yi Fang,Luyan Gu,Tao‐Guo,Xiaoli Su,Cheng‐Zhou,Ying‐Chen,Yi‐Liu,Xiaojun Guan,Xiaojun Xu,Xinzhen Yin,Minming Zhang,Zhihua Tao,Bao‐Rong Zhang
出处
期刊:European Journal of Neurology [Wiley]
卷期号:29 (12): 3590-3599 被引量:10
标识
DOI:10.1111/ene.15537
摘要

The insidious onset of Parkinson's disease (PD) makes early diagnosis difficult. Notably, idiopathic rapid eye movement sleep behavior disorder (iRBD) was reported as a prodrome of PD, which may represent a breakthrough for the early diagnosis of PD. However, currently there is no reliable biomarker for PD diagnosis. Considering that α-synuclein (α-Syn) and neuroinflammation are known to develop prior to the onset of clinical symptoms in PD, it was hypothesized that plasma total exosomal α-Syn (t-exo α-Syn), neural-derived exosomal α-Syn (n-exo α-Syn) and exosomal apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) may be potential biomarkers of PD.In this study, 78 PD patients, 153 probable iRBD patients (pRBD) and 63 healthy controls (HCs) were recruited. α-Syn concentrations were measured using a one-step paramagnetic particle-based chemiluminescence immunoassay, and ASC levels were measured using the Ella system.It was found that t-exo α-Syn was significantly increased in the PD group compared to the pRBD and HC groups (p < 0.0001), whilst n-exo α-Syn levels were significantly increased in both the PD and pRBD groups compared to HCs (p < 0.0001). Furthermore, although no difference was found in ASC levels between the PD and pRBD groups, there was a positive correlation between ASC and α-Syn in exosomes.Our results suggest that both t-exo α-Syn and n-exo α-Syn were elevated in the PD group, whilst only n-exo α-Syn was elevated in the pRBD group. Additionally, the adaptor protein of inflammasome ASC is correlated with α-Syn and may facilitate synucleinopathy.
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