[Clinical Role of M Protein in Multiple Myeloma and Lymphoma --Review].

M protein is often expressed in multiple myeloma and also can be detected in several lymphoma such as Waldenstrm macroglobulinaemia. M protein level can reflect the malignant degree and even genetic abnormality of multiple myeloma and lymphoma to some extent to predict the progress of the diseases, and the therapeutic response and prognosis of the disease can be evaluated by monitoring the M protein level and its change degree. This article reviews the role of M protein in the progression and prognosis of multiple myeloma and lymphoma, and discusses the differences in M protein expression between multiple myeloma and lymphoma, in order to provide new insights for clinical diagnosis, monitoring and evaluation of therapeutic effect.M蛋白在多发性骨髓瘤与淋巴瘤中的临床作用.M蛋白常表达于多发性骨髓瘤中，也可在华氏巨球蛋白血症等多种淋巴瘤中检测到。M蛋白水平可在一定程度上反映多发性骨髓瘤和淋巴瘤的恶性程度甚至是遗传异常从而预测疾病进展，并可通过监测M蛋白水平及其变化程度评估疾病治疗反应和预后。本文主要介绍M蛋白在多发性骨髓瘤和淋巴瘤中的进展判断及预后评估中的作用，并讨论M蛋白在多发性骨髓瘤和淋巴瘤中的表达差异，以期为临床提供疾病诊断、监测及疗效评估的新思路。.