光敏剂
光动力疗法
光热治疗
光合作用
单线态氧
肿瘤微环境
化学
生物物理学
体内
癌症研究
光化学
材料科学
纳米技术
生物化学
肿瘤细胞
氧气
生物
生物技术
有机化学
作者
Chenyang Yin,Zekun Wang,Chunxue Dai,Bangjia Yang,Wei‐Yun Wang,Endong Yang,Feng Guo,Cundong Fan,Pu Zhang,Jikui Sun,Dongdong Sun
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2023-01-01
卷期号:13 (5): 1632-1648
被引量:13
摘要
Background: Singlet oxygen ( 1 O2) has received considerable research attention in photodynamic therapy (PDT) due to its cytotoxic solid features.However, the inherent hypoxic state of the tumor microenvironment (TME) leads to the meager 1 O2 quantum yield of inorganic PDT reagents, and their application in vivo remains elusive.Methods: We developed a novel strategy to fabricate active photosynthetic bacteria/ photosensitizer/photothermal agent hybrids for photosynthetic tumor oxygenation and PDT and PTT tumor therapy under different laser irradiation sources.Photosynthetic bacteria combined with Ce6 photosensitizer and Au NPs photothermal agent, the obtained Bac@Au-Ce6 effectively targets tumor tissues and further enhances the tumor accumulation of Au-Ce6. Results:The results showed that the Au-Ce6-loaded engineered bacteria (Bac@Au-Ce6) maintained the photosynthetic properties of Syne.After i.v.injection, Bac@Au-Ce6 efficiently aggregates at tumor sites due to the tumor-targeting ability of active Syne.With 660 nm laser irradiation at the tumor site, the photoautotrophic Syne undergoes sustained photosynthetic O2 release and immediately activates O2 to 1 O2 via a loaded photosensitizer.PTT was subsequently imparted by 808 laser irradiations to enhance tumor killing further.Conclusions: This work provides a new platform for engineering bacteria-mediated photosynthesis to promote PDT combined with PTT multi-faceted anti-tumor.
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