更昔洛韦
间隙
超分子化学
泊洛沙姆407
角膜
单纯疱疹病毒
病毒学
生物医学工程
病毒
材料科学
化学
生物
分子
聚合物
眼科
人巨细胞病毒
医学
复合材料
泊洛沙姆
有机化学
共聚物
泌尿科
作者
Jingjing Hu,Xujiao Zhou,Sijia Chen,Di Yin,Yuhan Yang,Minjie Chen,Chunyi Gui,Yujia Cai,Jiaxu Hong,Yiyun Cheng
出处
期刊:Nano Today
[Elsevier]
日期:2023-06-01
卷期号:50: 101841-101841
被引量:5
标识
DOI:10.1016/j.nantod.2023.101841
摘要
Herpes simplex keratitis (HSK) caused by herpes simplex virus-1 infection of the cornea has taken a significant toll on the visual health of people worldwide. Anti-viral hydrogels are preferred in the treatment of HSK due to enhanced topical drug retention and reduced side effects, however, current polymer-based gelling systems usually generate clumpy or uneven gel layers on ocular surface, and are easily cleared by eyelid blinking. This study proposes a supramolecular gel co-assembled by all-small-molecule building blocks including ganciclovir and 2′-deoxyguanosine in the presence of potassium ions. The developed gel performs fascinating rheological and texture properties including high viscoelastic, good spread ability, and deformation recovery behavior, enabling the formation of a uniform and thin gel layer on ocular surface to resist the clearance by eyelid blinking and tear washing. The gel shows similar ocular convenience, but much longer drug retention in ocular tissues and higher therapeutic efficacy compared to the clinical ganciclovir gel on the primary and recurrent mouse HSK models, rabbit HSK models, and also efficiently inhibited the HSV-1 replication in ex vivo human corneal tissues. The results suggest that this all-small-molecule supramolecular gel could be a promising drug formulation for treating HSK. The main data supporting the results in this study are available within the paper and its Supplementary Information. The associated raw data and analyzed datasets are too large to be readily shared publicly, but they are available from the corresponding author on reasonable request.
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