孟德尔随机化
观察研究
随机对照试验
医学
疾病
维生素D与神经学
维生素D缺乏
糖尿病
维生素
重症监护医学
内科学
内分泌学
生物
生物化学
遗传变异
基因
基因型
作者
Shiyu Zhao,Frank Qian,Zhenzhen Wan,Xue Chen,Oscar H. Franco,Gang Liu
标识
DOI:10.1016/j.tem.2024.04.018
摘要
Numerous observational studies have demonstrated a significant inverse association between vitamin D status and the risk of major chronic disease, including type 2 diabetes (T2D), cardiovascular disease (CVD), and cancer. However, findings from Mendelian randomization (MR) studies and randomized controlled trials (RCTs) suggest minimal or no benefit of increased vitamin D levels. We provide an overview of recent literature linking vitamin D to major chronic diseases. Because emerging evidence indicates a potential threshold effect of vitamin D, future well-designed studies focused on diverse populations with vitamin D deficiency or insufficiency are warranted for a more comprehensive understanding of the effect of maintaining sufficient vitamin D status on the prevention of major chronic diseases.
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