表观遗传学
生物
后生
计算生物学
效应器
基因
遗传学
DNA甲基化
基因表达
细胞生物学
作者
Chenwei Zhou,Sarah Wagner,Fu‐Sen Liang
标识
DOI:10.1016/j.chembiol.2024.05.005
摘要
Epigenetic regulation plays a pivotal role in various biological and disease processes. Two key lines of investigation have been pursued that aim to unravel endogenous epigenetic events at particular genes (probing) and artificially manipulate the epigenetic landscape (editing). The concept of induced proximity has inspired the development of powerful tools for epigenetic research. Induced proximity strategies involve bringing molecular effectors into spatial proximity with specific genomic regions to achieve the probing or manipulation of local epigenetic environments with increased proximity. In this review, we detail the development of induced proximity methods and applications in shedding light on the intricacies of epigenetic regulation.
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