Novel and Convenient Synthesis of Deoxycholic Acid from Cholic Acid

In this article, a novel and practical approach was presented for the synthesis of deoxycholic acid (1) from cholic acid (2). The synthesis pathway involved the obtention of acid (20) from compound 2 via selective oxidation, followed by the condensation of 20 with p-toluenesulfonylhydrazine (23) to form hydrazones (21). Subsequently, product 1 was generated through a three-step reaction process involving reduction by NaBH4. The overall yield achieved 62.9%, with an HPLC purity of 100.00%. Structural confirmation of all compounds was performed using 1H NMR and 13C NMR spectroscopy as well as HRMS.