区域选择性
化学
钯
催化作用
吡咯
芳基
嘧啶
组合化学
反应条件
有机化学
药物化学
立体化学
烷基
作者
Yongxing Zhao,Rui Li,Qingzheng Zhao,Jinzhong Yao,Maozhong Miao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-05-18
卷期号:25 (21): 3978-3983
被引量:8
标识
DOI:10.1021/acs.orglett.3c01434
摘要
The unprecedented dimerizations of 2H-azirines have been developed under the catalysis of palladium and silver. Upon changing the reaction conditions, the fully aryl-substituted pyrrole and pyrimidine derivatives were furnished in moderate yields with regiospecificity, respectively. Control experiments uncovered distinct catalytic effects of two transition metals, and the proposed catalytic cycles plausibly rationalized the chemodivergence and regioselectivity.
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