Patient-specific cylinder templates for hybrid interstitial vaginal brachytherapy: Feasibility of automated 3-D design, 3D printing, and dosimetric outlook

医学 近距离放射治疗 3d打印 3D打印 医学物理学 生物医学工程 核医学 放射科 材料科学 放射治疗 复合材料
作者
Michael Kudla,François Bachand,Jocelyn Moore,Deidre Batchelar
出处
期刊:Brachytherapy [Elsevier]
卷期号:22 (4): 468-476 被引量:7
标识
DOI:10.1016/j.brachy.2023.03.002
摘要

PURPOSE Delivering highly conformal treatment plans for high-dose rate vaginal brachytherapy using commercially available applicators can be challenging. A partially automated workflow is presented for the in-house modeling and 3D printing of patient-specific cylindrical templates (PSCTs), which facilitate placement of flexible intracavitary and interstitial needles. To demonstrate feasibility, we compare PSCT treatment plans to retrospective interstitial brachytherapy plans delivered at our center. PSCTs derived from these plans were 3D printed to test the validity of the auto-design process. To facilitate clinical implementation, we validated the steam sterilization compatibility of PSCTs printed using polyetheretherketone (PEEK). METHODS AND MATERIALS Plans for ten patients treated using a combination of vaginal cylinder and interstitial needles were compared to PSCT-based plans created for the same patient. DVH parameters for the HRCTV (V100, V150, V200, D90) and OARs (D2 cm3) were evaluated, as well as the number of needles used and the total interstitial length. Each planned PSCT was printed and compared to the intended needle geometry. 3D printed models were sterilization validated by an independent contractor for an autoclave protocol. RESULTS PSCT plans demonstrated advantages over template based perineal BT in reducing the total interstitial needle length required while preserving or improving HRCTV and OAR dosimetry. All printed PSCTs matched planned geometry. CONCLUSIONS PSCTs stand to be an alternative to current HDR-BT templates/applicators for patients with vaginal and locally recurrent endometrial cancers. Clinically equivalent or improved treatment plans can be created and devices to deliver these plans can be accurately printed and sterilized.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
chen发布了新的文献求助30
1秒前
小马甲应助失眠夏之采纳,获得10
1秒前
赘婿应助爱睡觉的修勾勾采纳,获得10
1秒前
fabulousthee发布了新的文献求助10
2秒前
复杂白风发布了新的文献求助10
3秒前
3秒前
ydning33完成签到,获得积分10
4秒前
7秒前
失眠夏之完成签到,获得积分10
7秒前
超级天思完成签到,获得积分10
8秒前
yolanda发布了新的文献求助30
9秒前
大模型应助LX采纳,获得10
9秒前
努力努力123完成签到,获得积分10
9秒前
林夕发布了新的文献求助10
11秒前
健康的花生完成签到,获得积分10
13秒前
CipherSage应助拥抱爱莉采纳,获得10
14秒前
15秒前
不配.应助健康的花生采纳,获得10
17秒前
少年完成签到,获得积分10
17秒前
酷炫果汁完成签到 ,获得积分10
18秒前
LX发布了新的文献求助10
20秒前
景辣条应助科研通管家采纳,获得10
20秒前
21秒前
领导范儿应助科研通管家采纳,获得10
21秒前
英俊的铭应助科研通管家采纳,获得10
21秒前
21秒前
Akim应助科研通管家采纳,获得10
21秒前
浅尝离白应助科研通管家采纳,获得10
21秒前
充电宝应助科研通管家采纳,获得10
21秒前
顾矜应助科研通管家采纳,获得10
21秒前
共享精神应助科研通管家采纳,获得10
21秒前
21秒前
科研通AI2S应助科研通管家采纳,获得10
21秒前
22秒前
Ackeley完成签到,获得积分10
22秒前
24秒前
玩命做科研完成签到,获得积分10
24秒前
yolanda完成签到,获得积分20
24秒前
卫念烟发布了新的文献求助10
25秒前
25秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3136151
求助须知:如何正确求助?哪些是违规求助? 2787065
关于积分的说明 7780419
捐赠科研通 2443217
什么是DOI,文献DOI怎么找? 1298945
科研通“疑难数据库(出版商)”最低求助积分说明 625294
版权声明 600870