COVID-19 Vaccination Safety Profiles in Patients With Solid Tumour Cancers: A Systematic Review

医学 观察研究 接种疫苗 系统回顾 内科学 萎靡不振 不利影响 回顾性队列研究 梅德林 外科 病理 政治学 法学
作者
S.L. Shear,K. Shams,Jake Weisberg,Nima Hamidi,Steph Scott
出处
期刊:Clinical Oncology [Elsevier]
卷期号:35 (7): e421-e433 被引量:2
标识
DOI:10.1016/j.clon.2023.03.006
摘要

Abstract

Vaccination has become an essential means of protection for solid tumour patients against coronavirus disease 2019 (COVID-19). In this systematic review, we sought to identify common safety profiles of the COVID-19 vaccine in patients with solid tumours. A search of Web of Science, PubMed, EMBASE and Cochrane was conducted for studies in English full-text that reported side-effect data experienced by patients with cancer who were at least 12 years old with solid tumours or a recent history of solid tumours after receiving either one or multiple doses of the COVID-19 vaccination. Study quality was assessed with the Newcastle Ottawa Scale criteria. Acceptable study types were retrospective and prospective cohorts, retrospective and prospective observational studies, observational analyses and case series; systematic reviews, meta-analyses and case reports were excluded. Among local/injection site symptoms, the most commonly reported were injection site pain and ipsilateral axillary/clavicular lymphadenopathy, whereas the most commonly reported systemic effects were fatigue/malaise, musculoskeletal symptoms and headache. Most side-effects reported were characterised as mild to moderate. A thorough evaluation of the randomised controlled trials for each featured vaccine led to the conclusion that in the USA and abroad, the safety profile seen in patients with solid tumours is comparable with that seen in the general public.
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