免疫系统
脉络丛
神经科学
脑膜
免疫
淋巴系统
生物
脑功能
中枢神经系统
医学
免疫学
作者
Giulia Castellani,Tommaso Croese,Javier María Peralta Ramos,Michal Schwartz
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-04-07
卷期号:380 (6640)
被引量:83
标识
DOI:10.1126/science.abo7649
摘要
Contemporary studies have completely changed the view of brain immunity from envisioning the brain as isolated and inaccessible to peripheral immune cells to an organ in close physical and functional communication with the immune system for its maintenance, function, and repair. Circulating immune cells reside in special niches in the brain’s borders, the choroid plexus, meninges, and perivascular spaces, from which they patrol and sense the brain in a remote manner. These niches, together with the meningeal lymphatic system and skull microchannels, provide multiple routes of interaction between the brain and the immune system, in addition to the blood vasculature. In this Review, we describe current ideas about brain immunity and their implications for brain aging, diseases, and immune-based therapeutic approaches.
科研通智能强力驱动
Strongly Powered by AbleSci AI