氙气
急性肾损伤
肾
微气泡
吸入
医学
缺血
药理学
化学
内科学
麻醉
超声波
有机化学
放射科
作者
Jing Yang,Chaojin Chen,Xiaoyan Miao,Tienan Wang,Yu Guan,Linan Zhang,Sufang Chen,Zheng Zhang,Zhengyuan Xia,Jiayi Kang,Haobo Li,Tinghui Yin,Ziqing Hei,Weifeng Yao
标识
DOI:10.1002/adhm.202203359
摘要
Inhalation of xenon gas improves acute kidney injury (AKI). However, xenon can only be delivered through inhalation, which causes non-specific distribution and low bioavailability of xenon, thus limiting its clinical application. In this study, xenon is loaded into platelet membrane-mimicking hybrid microbubbles (Xe-Pla-MBs). In ischemia-reperfusion-induced AKI, intravenously injected Xe-Pla-MBs adhere to the endothelial injury site in the kidney. Xe-Pla-MBs are then disrupted by ultrasound, and xenon is released to the injured site. This release of xenon reduced ischemia-reperfusion-induced renal fibrosis and improved renal function, which are associated with decreased protein expression of cellular senescence markers p53 and p16, as well as reduced beta-galactosidase in renal tubular epithelial cells. Together, platelet membrane-mimicking hybrid microbubble-delivered xenon to the injred site protects against ischemia-reperfusion-induced AKI, which likely reduces renal senescence. Thus, the delivery of xenon by platelet membrane-mimicking hybrid microbubbles is a potential therapeutic approach for AKI.
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