阿托品
环加成
对映选择合成
有机催化
组合化学
轴手性
催化作用
化学
分子
手性(物理)
计算化学
立体化学
有机化学
物理
夸克
量子力学
手征对称破缺
Nambu–Jona Lasinio模型
作者
Wei-Yun Cai,Qian-Ni Ding,Ling Zhou,Jie Chen
出处
期刊:Molecules
[MDPI AG]
日期:2023-05-24
卷期号:28 (11): 4306-4306
被引量:3
标识
DOI:10.3390/molecules28114306
摘要
Atropisomeric molecules are present in many natural products, biologically active compounds, chiral ligands and catalysts. Many elegant methodologies have been developed to access axially chiral molecules. Among them, organocatalytic cycloaddition and cyclization have attracted much attention because they have been widely used in the asymmetric synthesis of biaryl/heterobiaryls atropisomers via construction of carbo- and hetero-cycles. This strategy has undoubtedly become and will continue to be a hot topic in the field of asymmetric synthesis and catalysis. This review aims to highlight the recent advancements in this field of atropisomer synthesis by using different organocatalysts in cycloaddition and cyclization strategies. The construction of each atropisomer, its possible mechanism, the role of catalysts, and its potential applications are illustrated.
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