Synthetic applications of p-toluenesulfonyl chloride: A recent update

The p-toluenesulfonyl chloride is one of the most common reagents for converting the poor leaving group (OH) into a good leaving group (OTs). Activating the hydroxyl group enables the chemists to prepare a wide range of functional groups from the hydroxyl compound. Besides, it acts as a protecting agent, chlorinating agent, dehydrating agent, arylating agent, and catalyst. This review describes the recent synthetic applications of p-toluenesulfonyl chloride and discusses the mechanism of reactions wherever applicable.