试剂
化学
三氟甲基
亲核细胞
组合化学
反应性(心理学)
药物化学
离子
有机化学
催化作用
医学
病理
替代医学
烷基
作者
Yuhao Yang,Seyedesahar Miraghaee,R. David Pace,Teruo Umemoto,Gerald B. Hammond
标识
DOI:10.1002/anie.202306095
摘要
A novel, air and thermally stable, yet highly reactive trifluoromethylthiolating reagent, CF3 SO2 SCF3 (1), was prepared easily in one step from commercially inexpensive CF3 SO2 Na and Tf2 O. 1 is a highly versatile and atom-efficient reagent that can generate one equivalent of CF3 S+ , two equivalents of CF3 S- , or a combination of CF3 S⋅/CF3 ⋅ species. Many high-yielding CF3 S reactions of C, O, S, and N-nucleophiles were achieved, including the simple-step preparations of many reported CF3 S reagents. 1 delivered a hitherto hard-to-synthesize ArOSCF3 that was followed by a novel CF3 SII -rearrangement. Through Cu or TDAE/Ph3 P combinations, 1 generated two equivalents of CF3 S anion species, and the photo-catalyzed reactions of alkenes with 1 provided CF3 /CF3 S-containing products in high atom-efficiency.
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