淋巴水肿
淋巴管新生
医学
淋巴系统
免疫系统
病态的
炎症
失调家庭
疾病
免疫学
病理
内科学
癌症
转移
临床心理学
乳腺癌
出处
期刊:Lymphatic Research and Biology
[Mary Ann Liebert]
日期:2023-12-01
卷期号:21 (6): 556-564
被引量:3
标识
DOI:10.1089/lrb.2023.0002
摘要
Lymphedema is a debilitating disease characterized by extremity edema, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatics, often with lymphatic injury secondary to the treatment of malignancies. Emerging evidence has shown that immune dysfunction regulated by T cells plays a pivotal role in development of lymphedema. Specifically, Th1, Th2, Treg, and Th17 cells have been identified as critical regulators of pathological changes in lymphedema. In this review, our aim is to provide an overview of the current understanding of the roles of CD4+ T cells, including Th1, Th2, Treg, and Th17 subsets, in the progression of lymphedema and to discuss associated therapies targeting T cell inflammation for management of lymphedema.
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