生物传感器
催化作用
选择性
表面改性
纳米材料
石墨烯
纳米化学
纳米颗粒
氧化物
分析物
混合材料
组合化学
化学工程
纳米
化学
纳米技术
材料科学
色谱法
有机化学
物理化学
复合材料
工程类
作者
Nannan Lu,Yu Liu,Xin Yan,Zhiyuan Xu,Yue Xing,Yu Song,Puyu Zhao,Meihan Liu,Yue Gu,Zhiquan Zhang,Shenqiang Zhai
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2022-07-28
卷期号:5 (8): 11361-11370
被引量:14
标识
DOI:10.1021/acsanm.2c02446
摘要
Development of hybrid nanozymes with high catalytic efficiency is of critical importance for enzyme mimics in biological catalytic fields. Herein, we reported a polydopamine (PDA) surface modification-assisted pyrolysis strategy for preparing CoO nanoparticles/N-doped carbon sheets/reduced graphene oxide composites (CoO/N-CS-rGO). In this strategy, PDA with abundant amines and imines could serve as an eco-friendly N-contained precursor and a connecting agent between GO matrix and CoO. Due to the superior conductivity of N-CS-rGO, synergistic catalysis between CoO nanoparticles (NPs) and N-CS-rGO, and intrinsic oxidase-like characteristic, the CoO/N-CS-rGO was used as an ultrasensitive signal amplification platform for simultaneously analyzing dopamine (DA) and uric acid (UA) in a neutral solution. Significantly, the fabricated electrochemical sensor showed ultrahigh sensitivities of 1378 μA mM–1 for DA and 1393 μA mM–1 for UA. The linear range of 0.5–110 μM for DA and 1–125 μM for UA could be obtained by this sensor. Furthermore, the stability and selectivity of the CoO/N-CS-rGO-based hybrid biosensor were evaluated. The results showed that the biosensor performed good stability and brilliant selectivity against interfering analytes. Also, the CoO/N-CS-rGO/GCE was adopted to monitor two analytes in human serum samples with high accuracy. This work provides an efficient PDA-assisted synthetic strategy to prepare hybrid nanomaterials and shows broad prospects for biosensing, biotechnology, and clinical diagnosis.
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