化学
区域选择性
立体中心
多米诺骨牌
对映选择合成
催化作用
基质(水族馆)
组合化学
邻接
赫克反应
级联反应
钯
立体化学
有机化学
海洋学
地质学
作者
Dong‐Chao Wang,Tingting Yang,Gui‐Rong Qu,Hai‐Ming Guo
标识
DOI:10.1021/acs.joc.2c01768
摘要
A Pd/phase-transfer catalyst cooperatively catalyzed domino Heck/allylation reaction is first reported, which represents interesting substrate-dependent regioselectivity. Under the same conditions, Ts-protected N-(2-iodophenyl)allenamides produced only linear allylation products, while Cbz, Ac, or Boc-protected N-(2-iodophenyl)allenamides and N-(2-iodobenzoyl)allenamides with various compounds generated branch allylation products with an exocylic C═C bond and two vicinal stereocenters. Up-scale syntheses and diverse fused cyclization transformations of products were then carried out. The enantioselective version for the domino process was studied.
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