Adjuvant role of probiotics in allergen-specific immunotherapy

Allergy are a global public health problem with serious consequences for human health. Many studies have confirmed that probiotics can play an active role in the treatment of allergies, and early intervention of probiotics can significantly reduce the incidence in infants and young children. As an adjuvant of allergen-specific immunotherapy (AIT), probiotics also show advantages in improving the therapeutic effect and reducing side effects. This paper reviewed the research progress of probiotics in the prevention and alleviation of allergies, focused on the use of probiotics as adjuvants for AIT, and pointed out the possibility of probiotics' extracellular proteins, extracellular vesicles, metabolites, and Toll-like Receptors (TLR) agonist analog as AIT adjuvant alone.