Vitamin D protects against depression: Evidence from an umbrella meta-analysis on interventional and observational meta-analyses

荟萃分析 医学 维生素D与神经学 萧条(经济学) 优势比 内科学 观察研究 安慰剂 置信区间 随机对照试验 维生素D缺乏 维生素 病理 替代医学 宏观经济学 经济
作者
Vali Musazadeh,Majid Keramati,Faezeh Ghalichi,Zeynab Kavyani,Zohreh Ghoreishi,Kamar Allayl Alras,Naryman Ismail Albadawi,Abdullah Salem,Mohamed Ismail Albadawi,Raghad Salem,Ahmed Abu‐Zaid,Meysam Zarezadeh,Rania A. Mekary
出处
期刊:Pharmacological Research [Elsevier BV]
卷期号:187: 106605-106605 被引量:19
标识
DOI:10.1016/j.phrs.2022.106605
摘要

Meta-analyses of interventional and observational studies investigating the efficacy and the relationship between vitamin D and depression provided inconsistent results. The current umbrella meta-analysis was conducted to assess the available evidence and provide a conclusive outcome in this regard. The following international databases were systematically searched till March 2022: PubMed, Scopus, Embase, Web of Science, and Google Scholar. Random-effects model was carried out to calculate the pooled point estimates and their respective 95 % confidence intervals (CI). Ten meta-analyses of randomised controlled trials (RCTs) revealed significant reduction in depression symptoms comparing participants on vitmain D supplements to those on placebo (Pooled standardised mean difference: - 0.40; 95 % CI: - 0.60, - 0.21, p < 0.01: I2 = 89.1 %, p < 0.01). Four meta-analyses of cohort studies (with one having two subgroups) revealed that participants with lower levels of serum vitamin D were at increased odds of depression than those with higher levels of serum vitamin D (Pooled odds ratio: 1.60; 95 % CI: 1.08, 2.36, p < 0.01; I2 = 91.3 %, p < 0.01). The present umbrella meta-analysis confirms the potential benefits of vitamin D supplementation and higher serum vitamin D levels in reducing the development and symptoms of depression.
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