转录组
神经科学
生物
神经影像学
大脑皮层
基因表达
基因
遗传学
作者
Xiaolin Zhang,Weijia Gao,Weifang Cao,Jinpeng Niu,Yongxin Guo,Dong Cui,Guanghui Yu,Ruhai Dou,Qing Jiao,Jianfeng Qiu,Linyan Su,Guangming Lu
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2023-03-16
卷期号:33 (12): 7540-7552
标识
DOI:10.1093/cercor/bhad059
摘要
Abstract Bipolar disorder (BD) is a heritable psychiatric disorder with a complex etiology that is often associated with cortical alterations. Morphometric studies in adults with BD are well established; however, few have examined cortical changes in pediatric BD (PBD). Additionally, the correlation between cortical thickness (CT) changes in PBD and gene expression remains elusive. Here, we performed an integrative analysis using neuroimaging data from 58 PBD individuals and the Allen human brain transcriptomic dataset. We applied partial least squares (PLS) regression analysis on structural MRI data and cortical gene expression, enrichment and specific cell type analysis to investigate the genetic correlates of CT alterations in PBD. We found the expression levels of PBD-related genes showed significant spatial correlations with CT differences. Further enrichment and specific cell type analysis revealed that transcriptome signatures associated with cortical thinning were enriched in synaptic signaling, ion channels, astrocytes, and excitatory neurons. Neurodevelopmental patterns of these genes showed significantly increased expression in the cerebellum, cortex, and subcortical regions during the adolescence period. These results highlight neurodevelopmental transcriptional changes could account for most of the observed correlations with CT differences in PBD, which offers a novel perspective to understand biological conceptualization mechanisms for the genetic correlates of CT alterations.
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