锥体细胞
精神分裂症(面向对象编程)
神经科学
灵长类动物
前额叶皮质
转录组
电池类型
心理学
生物
细胞
认知
海马体
精神科
遗传学
基因表达
基因
作者
Dominique Arion,John F. Enwright,Guillermo González‐Burgos,David A. Lewis
标识
DOI:10.1176/appi.ajp.20230541
摘要
In schizophrenia, impaired working memory is associated with transcriptome alterations in layer 3 pyramidal neurons (L3PNs) in the dorsolateral prefrontal cortex (DLPFC). Distinct subtypes of L3PNs that send axonal projections to the DLPFC in the opposite hemisphere (callosal projection [CP] neurons) or the parietal cortex in the same hemisphere (ipsilateral projection [IP] neurons) play critical roles in working memory. However, how the transcriptomes of these L3PN subtypes might shift during late postnatal development when working memory impairments emerge in individuals later diagnosed with schizophrenia is not known. The aim of this study was to characterize and compare the transcriptome profiles of CP and IP L3PNs across developmental transitions from prepuberty to adulthood in macaque monkeys.
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