蜕膜化
多囊卵巢
不育
子宫内膜异位症
怀孕
自分泌信号
卵巢癌
生物
生物信息学
女性不育
子痫前期
医学
内科学
癌症
内分泌学
糖尿病
胰岛素抵抗
遗传学
受体
作者
Masuma Khatun,Vijayachitra Modhukur,Terhi Piltonen,Juha S. Tapanainen,Andres Salumets
标识
DOI:10.1210/endocr/bqae110
摘要
Abstract Stanniocalcin (STC) 1 and 2 serve as anti-hyperglycemic polypeptide hormones with critical roles in regulating calcium and phosphate homeostasis. They additionally function as paracrine and/or autocrine factors involved in numerous physiological processes, including female reproduction. STC1 and STC2 contribute to the pathophysiology of several diseases, including female infertility- and pregnancy-associated conditions, and even tumorigenesis of reproductive organs. This comprehensive review highlights the dynamic expression patterns and potential dysregulation of STC1 and STC2, restricted to female fertility, and infertility- and pregnancy-associated diseases and conditions, such as endometriosis, polycystic ovary syndrome (PCOS), abnormal uterine bleeding, uterine polyps, and pregnancy complications, like impaired decidualization, preeclampsia, and preterm labor. Furthermore, the review elucidates the role of dysregulated STC in the progression of cancers of the reproductive system, including endometrial, cervical, and ovarian cancers. Additionally, the review evaluates the expression patterns and prognostic significance of STC in gynecological cancers by utilizing existing public datasets from the Cancer Genome Atlas (TCGA), to help decipher the multifaceted roles of these pleiotropic hormones in disease progression. Understanding the intricate mechanisms by which STC proteins influence all these reviewed conditions could lead to the development of targeted diagnostic and therapeutic strategies in the context of female reproductive health and oncology.
科研通智能强力驱动
Strongly Powered by AbleSci AI