Uric acid levels and cardiovascular and cerebrovascular diseases: a Mendelian randomization study

孟德尔随机化 医学 内科学 全基因组关联研究 心房颤动 心脏病学 冲程(发动机) 遗传关联 冠状动脉疾病 心房扑动 尿酸 单核苷酸多态性 遗传学 遗传变异 基因型 工程类 基因 生物 机械工程
作者
Xiaowen Hou,Kaiwen Cen,Yunfeng Zhu,Zhi Ming Zhu,Zhiyu Zhang,Feng Xu
出处
期刊:Cerebrovascular Diseases [Karger Publishers]
卷期号:: 1-13 被引量:1
标识
DOI:10.1159/000541624
摘要

Introduction: The relationship between uric acid (UA) levels and cardiovascular and cerebrovascular diseases (CCVD) is controversial. A two-sample Mendelian randomization (MR) study was conducted to explore the causal effects of UA levels on CCVD. Methods: Genetic variants strongly associated with UA levels were selected as instrumental variables from the Genome-Wide Association Study (GWAS) dataset. The GWAS data, sourced from the Global Urate Genetics Consortium (GUGC), comprised a sample size of 110,347 individuals. The selected CCVD outcomes included stroke, coronary artery disease (CAD), as well as atrial fibrillation and flutter. The primary analytical approach employed the inverse-variance weighted (IVW) method, supplemented by MR-Egger and weighted median as complementary methods. Sensitivity analysis was performed to test heterogeneity and pleiotropy. Results: The MR analysis results indicated a causal association between UA levels and stroke (OR: 1.002; 95% CI: 1.000-1.003; p = 0.036), CAD (OR: 1.118; 95% CI: 1.044-1.197; p = 0.001), as well as atrial fibrillation and flutter (OR: 1.141; 95% CI: 1.037- 1.256; p = 0.007). The results of MR-Egger and weighted median methods confirmed the direction of the IVW results, enhancing the robustness of the findings. No significant anomalies were detected in the sensitivity analysis. Conclusion: The MR study suggests that UA levels exert causal effects on stroke, CAD, as well as atrial fibrillation and flutter.

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