Acute necrotizing encephalopathy infected with the SARS-CoV-2 in children: case series and literature review of clinical outcomes with the use of Tocilizumab

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes acute necrotizing encephalopathy (ANE), which has a high mortality rate and severe sequelae. This study aimed to identify ANE early and evaluate the usefulness of tocilizumab in ANE treatment.