清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Congenital Cytomegalovirus Infection: Update on Screening, Diagnosis and Treatment

医学 怀孕 巨细胞病毒 黄疸 儿科 产科 免疫学 病毒性疾病 病毒 内科学 疱疹病毒科 遗传学 生物
作者
A. Khalil,Paul T. Heath,Christina Jones,Aung Soe,Y. Ville
出处
标识
DOI:10.1111/1471-0528.17966
摘要

Plain language summary Cytomegalovirus (CMV) is the most common cause of viral infection in newborn babies, and affects 1 in 200 of all live born infants in high‐income countries; and 1 in 71 in low‐ and middle‐income countries. It is a major cause of hearing loss and brain damage. Women may get CMV infection for the first time during pregnancy (primary infection) or may experience ‘non‐primary’ infection, either by reactivation of previous CMV infection or by a new infection with a different strain of the virus. The most common source of infection to pregnant women is the saliva and urine of young children. Therefore, all pregnant women, especially those in regular contact with young children, should be informed about hygiene‐based measures to reduce the risks, e.g. handwashing. The UK National Screening Committee recommends against universal antenatal or newborn screening for CMV. Testing for CMV is usually offered only to women who develop symptoms of influenza, glandular fever or hepatitis (liver inflammation) during pregnancy, or for those whom a routine ultrasound scan detects fetal anomalies that suggests possible CMV infection. The risk of harm to the fetus is greatest following primary CMV infection of the woman in early pregnancy, and appears to be very low following infection after 12 weeks of pregnancy. Babies with CMV infection at birth may have jaundice, a rash, enlarged liver or spleen, a small brain, or be small for their gestational age. Around 1 in 8 babies born with CMV infection will have clinically detectable signs at birth. The rest will not have any features detectable by clinical examination alone. Therefore, all infants with CMV infection at birth should be followed up at a minimum of up to 2 years of age or later, depending upon the disease status, to check hearing and brain development. Following primary CMV infection in the first 12 weeks of pregnancy, if the woman starts taking the antiviral medicine valaciclovir (valacyclovir) it reduces the risk of the baby becoming infected. Where CMV infection of the fetus in the womb has been confirmed (by amniocentesis, for example), regular ultrasound scans should be offered every 2–3 weeks until birth. Detailed assessment of the fetal brain is an essential part of these scans. Where maternal CMV infection occurs, but fetal infection is not confirmed, repeated ultrasound scans of the fetus should be offered every 2–3 weeks until birth. In infected fetuses, as well as ultrasound scans, an MRI scan of the brain should be offered at 28–32 weeks of gestation (and sometimes repeated 3–4 weeks later) to assess for any signs of harm to the fetal brain. All babies born to women with confirmed or suspected CMV infection should be tested for CMV with a urine or saliva sample within the first 21 days of life. In newborns with symptomatic CMV infection at birth, treatment with antiviral medicine (valganciclovir or ganciclovir) can reduce hearing loss in 5 out of 6 babies, and improve long‐term brain development outcomes in some. There is no licensed vaccine for CMV.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
青春梦完成签到 ,获得积分10
16秒前
Leo完成签到 ,获得积分10
56秒前
YumiPg完成签到,获得积分10
1分钟前
黙宇循光完成签到 ,获得积分10
1分钟前
相南相北完成签到 ,获得积分10
1分钟前
凶狠的盛男完成签到 ,获得积分10
2分钟前
yuehan完成签到 ,获得积分10
2分钟前
梓歆完成签到 ,获得积分10
2分钟前
闪闪的谷梦完成签到 ,获得积分10
2分钟前
这个文献你有么完成签到,获得积分10
2分钟前
vitamin完成签到 ,获得积分10
2分钟前
研友_nEWRJ8完成签到,获得积分10
2分钟前
田様应助科研通管家采纳,获得10
3分钟前
刘玲完成签到 ,获得积分10
3分钟前
jingjili完成签到,获得积分0
4分钟前
4分钟前
jingjili发布了新的文献求助10
4分钟前
拓跋雨梅完成签到 ,获得积分0
5分钟前
郭星星完成签到,获得积分10
5分钟前
个性仙人掌完成签到 ,获得积分10
5分钟前
Echoheart完成签到,获得积分10
5分钟前
咯咯咯完成签到 ,获得积分10
6分钟前
淡淡醉波wuliao完成签到 ,获得积分10
6分钟前
even完成签到 ,获得积分10
6分钟前
研友_Z119gZ完成签到 ,获得积分10
6分钟前
沙海沉戈完成签到,获得积分0
6分钟前
Shandongdaxiu完成签到 ,获得积分10
7分钟前
如意的馒头完成签到 ,获得积分10
7分钟前
kenchilie完成签到 ,获得积分10
7分钟前
Summer_Xia完成签到 ,获得积分10
10分钟前
11分钟前
小郭发布了新的文献求助20
11分钟前
不安青牛应助偷西瓜的猹采纳,获得10
11分钟前
11分钟前
小郭发布了新的文献求助10
12分钟前
吉吉完成签到 ,获得积分10
12分钟前
12分钟前
小马甲应助小郭采纳,获得10
12分钟前
apathetic完成签到,获得积分10
12分钟前
12分钟前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162343
求助须知:如何正确求助?哪些是违规求助? 2813330
关于积分的说明 7899736
捐赠科研通 2472848
什么是DOI,文献DOI怎么找? 1316533
科研通“疑难数据库(出版商)”最低求助积分说明 631375
版权声明 602142