生物
轴突
轴突引导
神经科学
奈特林
神经系统
信号转导
斑马鱼
轴突丘
秀丽隐杆线虫
泛素连接酶
细胞生物学
泛素
遗传学
基因
作者
Muriel Desbois,Brock Grill
出处
期刊:Development
[The Company of Biologists]
日期:2024-09-01
卷期号:151 (17)
摘要
ABSTRACT Spatially and temporally accurate termination of axon outgrowth, a process called axon termination, is required for efficient, precise nervous system construction and wiring. The mechanosensory neurons that sense low-threshold mechanical stimulation or gentle touch have proven exceptionally valuable for studying axon termination over the past 40 years. In this Review, we discuss progress made in deciphering the molecular and genetic mechanisms that govern axon termination in touch receptor neurons. Findings across model organisms, including Caenorhabditis elegans, Drosophila, zebrafish and mice, have revealed that complex signaling is required for termination with conserved principles and players beginning to surface. A key emerging theme is that axon termination is mediated by complex signaling networks that include ubiquitin ligase signaling hubs, kinase cascades, transcription factors, guidance/adhesion receptors and growth factors. Here, we begin a discussion about how these signaling networks could represent termination codes that trigger cessation of axon outgrowth in different species and types of mechanosensory neurons.
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