青枯菌
病菌
生物
毒力
微生物学
寄主(生物学)
过氧化氢酶
植物免疫
植物对草食的防御
γ-氨基丁酸
氧化应激
基因
生物化学
拟南芥
遗传学
突变体
受体
作者
Wei Liu,Yushu Wang,Tuo Ji,Hui Li,Qinghua Shi,Chuanyou Li,Jin‐Wei Wei,Biao Gong
摘要
Summary Soil nitrogen (N) significantly influences the interaction between plants and pathogens, yet its impact on host defenses and pathogen strategies via alterations in plant metabolism remains unclear. Through metabolic and genetic studies, this research demonstrates that high‐N‐input exacerbates tomato bacterial wilt by altering γ‐aminobutyric acid (GABA) metabolism of host plants. Under high‐N conditions, the nitrate sensor NIN‐like protein 7 (SlNLP7) promotes the glutamate decarboxylase 2/4 ( SlGAD2/4 ) transcription and GABA synthesis by directly binding to the promoters of SlGAD2/4 . The tomato plants with enhanced GABA levels showed stronger immune responses but remained susceptible to Ralstonia solanacearum . This led to the discovery that GABA produced by the host actually heightens the pathogen's virulence. We identified the R. solanacearum LysR‐type transcriptional regulator OxyR protein, which senses host‐derived GABA and, upon interaction, triggers a response involving protein dimerization that enhances the pathogen's oxidative stress tolerance by activating the expression of catalase ( katE / katGa ). These findings reveal GABA's dual role in activating host immunity and enhancing pathogen tolerance to oxidative stress, highlighting the complex relationship between tomato plants and R. solanacearum , influenced by soil N status.
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