Hippophae rhamnoides L. leaf extracts alleviate diabetic nephropathy via attenuation of advanced glycation end product-induced oxidative stress in db/db mice

In diabetes, excessive formation and accumulation of advanced glycation end products induce oxidative stress, leading to chronic renal failure. The leaves of Hippophae rhamnoides L. (SBL) attenuated oxidative stress by modulating the AGEs-RAGE axis.