生物
TLR2型
细胞生物学
信使核糖核酸
癌症研究
基因
信号转导
遗传学
TLR4型
作者
Jing Ye,Yuting Wu,Yao Chen,Yiyue Ren,Xiaohua Jiang,Zhihuai Dong,Jingna Zhang,Minghua Jin,Xiaozhen Chen,Zhanggui Wang,Mang Xiao
标识
DOI:10.1038/s41420-023-01589-6
摘要
Hypopharyngeal squamous cell carcinoma (HPSCC) is one of the most aggressive cancers and is notorious for its extremely poor prognosis. However, very few molecular biological studies have been performed. As a novel method of epigenetic gene modulation, N6-methyladenosine (m6A) RNA modification occurs in HPSCC. The expression of the m6A demethylase AlkB homolog 5 (ALKBH5) is frequently downregulated in human HPSCC. Furthermore, we found that ALKBH5 impaired cell proliferation by regulating human Toll-like receptor 2 (TLR2) in an m6A-dependent manner in HPSCC cells. ALKBH5 decreased TLR2 m6A modification, which could be recognized by the m6A readers IGF2BP2 and YTHDF1. IGF2BP2 facilitates TLR2 mRNA stability, whereas YTHDF1 promotes TLR2 mRNA translation. The current work uncovered a critical function of ALKBH5 in TLR2 regulation and provides a novel role for m6A demethylation of mRNA in HPSCC. The inhibition of m6A modification of ALKBH5 in HPSCC deserves further clinical investigation.
科研通智能强力驱动
Strongly Powered by AbleSci AI