骨骼肌
生物
内分泌学
内科学
2型糖尿病
转录因子
肥胖
基因表达
胰岛素受体
糖尿病
基因
胰岛素抵抗
医学
遗传学
作者
Pavel A. Makhnovskii,Egor M. Lednev,A. O. Gavrilova,Nadia S. Kurochkina,Tatiana F. Vepkhvadze,Марина Владимировна Шестакова,Daniil V. Popov
出处
期刊:Physiological Genomics
[American Physiological Society]
日期:2023-08-07
卷期号:55 (10): 468-477
被引量:2
标识
DOI:10.1152/physiolgenomics.00046.2023
摘要
In skeletal muscle of metabolically healthy subjects, a typical single meal normalized to body mass induces activation of various transcription factors, expression of numerous receptor tyrosine kinases associated with the insulin signaling cascade, and transcription regulators. In skeletal muscle of obese individuals without and with type 2 diabetes, this signaling network is poorly regulated at the transcriptional level, indicating dysregulation of the early gene response to a mixed meal.
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